New quantitative trait loci for carotid atherosclerosis identified in an intercross
نویسندگان
چکیده
1 derived from apolipoprotein E-deficient mouse strains 2 3 Short title: QTLs for carotid Atherosclerosis 4 5 *Jessica S. Rowlan, *Zhimin Zhang, Qian Wang, Yan Fang, Weibin Shi 6 7 Departments of Radiology & Medical Imaging and of Biochemistry & Molecular Genetics, 8 University of Virginia, Charlottesville, VA 22908 9 10 11 Correspondence to: Weibin Shi, MD, PhD 12 University of Virginia 13 Fontaine Research Park 14 P.O. Box 801339 15 480 Ray C Hunt Drive 16 Charlottesville, VA 22908 17 Fax: (434) 982 5680 18 Phone: (434) 243 9420 19 E-mail: [email protected] 20 21
منابع مشابه
New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains
Carotid atherosclerosis is the primary cause of ischemic stroke. To identify genetic factors contributing to carotid atherosclerosis, we performed quantitative trait locus (QTL) analysis using female mice derived from an intercross between C57BL/6J (B6) and BALB/cJ (BALB) apolipoprotein E (Apoe(-/-)) mice. We started 266 F(2) mice on a Western diet at 6 wk of age and fed them the diet for 12 wk...
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BACKGROUND AND PURPOSE Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerotic lesion formation in the carotid arteries on the apolipoprotein E-deficient (apoE(-/-)) background when fed a Western diet. Quantitative trait locus analysis was performed on an intercross between B6.apoE(-/-) and C3H.apoE(-/-) mice to determine genetic factors contributing t...
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Atherosclerosis in the carotid arteries is a major cause of ischemic stroke, which accounts for 85% of all stroke cases. Genetic factors contributing to carotid atherosclerosis remain poorly understood. The aim of this study was to identify chromosomal regions harboring genes contributing to carotid atherosclerosis in mice. From an intercross between BALB/cJ (BALB) and SM/J (SM) apolipoprotein ...
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